The Appalachian region is rich in biodiversity that is highly threatened by energy production, development, and a host of other factors. Large-scale impacts such as climate change will play out within this context, affecting habitats and species in different ways. Understanding the vulnerability of various species and habitats within the Appalachian LCC to such changes is of critical importance. Identifying the steps needed to acquire vulnerability information and then using this information to inform adaptation and mitigation strategies is a major research priority of the LCC.